Use and Care Manual

Material Safety Data Sheet
Version: 1.4
03/28/2008
GE510 3TG-Tube (0.198LB-0.090KG)
Silicone Rubber Sealant
Page 5/8
10. STABILITY AND REACTIVITY
STABILITY
Stable
HAZARDOUS POLYMERIZATION
Will not occur
HAZARDOUS THERMAL DECOMPOSITION / COMBUSTION PRODUCTS
Methanol; Carbon dioxide (CO2); Formaldehyde; Carbon monoxide; Ammonia; Silicon dioxide.;
Oxides of nitrogen.
INCOMPATIBILITY (MATERIALS TO AVOID)
None known.
CONDITIONS TO AVOID
None known.
11. TOXICOLOGICAL INFORMATION
ACUTE ORAL
Remarks: Unknown
ACUTE DERMAL
Remarks: Unknown
ACUTE INHALATION
Remarks: Unknown
OTHER
Octamethylcyclotetrasiloxane Ingestion: Rodents given large doses via oral gavage of
octamethylcyclotetrasiloxane (1600 mg/kg day, 14 days) developed increased liver weights relative to
unexposed control animals due to hepatocellular hyperplasia (increased number of liver cells which
appear normal) as well as hypertrophy (increased cell size). Inhalation: In inhalation studies,
laboratory rodents exposed to octamethylcyclotetrasiloxane (300 ppm five days week, 90 days)
developed increased liver weights in female animals relative to unexposed control animals. When the
exposure was stopped, liver weights returned to normal. Microscopic examination of the liver cells did
not show any evidence of pathology. Inhalation studies utililizing laboratory rabbits and guinea pigs
showed no effects on liver weights. Inhalation exposures typical of industrial usage (5-10 ppm)
showed no toxic effects in rodents. Range finding reproductive studies were conducted (whole body
inhalation, 70 days prior to mating, through mating, gestation and lactation) with
octamethylcyclotetrasiloxane (D4). Rats were exposed to 70 and 700 ppm. In the 700 ppm group,
there was a statistically significant reduction in mean litter size and in implantation sites. No D4
related clinical signs were observed in the pups and no exposure related pathological findings were
found. Interim results from a two generation reproductive study in rats exposed to 500 and 700 ppm
D4 (whole body inhalation, 70 days prior to mating, through mating, gestation and lactation) resulted in
a statistically significant decrease in live mean litter size as well as extended periods of off-spring