SDS

Version: 1.0
Revision Date: 10/25/2019
SDS_US - RE1000030030
14/26
Repeated dose toxicity
Product:
No data available.
Specified substance(s):
Benzene, methyl-
LOAEL (Rat(Female, Male), Oral, 13 Weeks): 1,250 mg/kg (Target
Organ(s): Liver, Kidney) Oral Experimental result, Key study
NOAEL (Rat(Female, Male), Inhalation): 625 ppm(m) Inhalation
Experimental result, Key study
NOAEL (Rat(Female, Male), Inhalation - vapor): 2,355 mg/l Inhalation
Experimental result, Key study
Butane
LOAEL (Rat(Female, Male), Inhalation, >= 28 d): 12,000 ppm(m) Inhalation
Experimental result, Key study
NOAEL (Rat(Female, Male), Inhalation, >= 28 d): 4,000 ppm(m) Inhalation
Experimental result, Key study
Propane
NOAEL (Rat(Female, Male), Inhalation, >= 28 d): 4,000 ppm(m) Inhalation
Experimental result, Key study
LOAEL (Rat(Female, Male), Inhalation, >= 28 d): 12,000 ppm(m) Inhalation
Experimental result, Key study
Distillates (petroleum),
light distillate
hydrotreating process,
low-boiling
NOAEL (Rat(Female, Male), Inhalation): 9,840 mg/m3 Inhalation
Experimental result, Key study
NOAEL (Rat(Female, Male), Dermal, 5 - 28 d): 3,750 mg/kg Dermal
Experimental result, Key study
NOAEL (Rat(Male), Oral, 28 d): < 500 mg/kg Oral Experimental result,
Supporting study
Carbon black
NOAEL (Rat(Female), Oral, 52 - 104 Weeks): 52 mg/kg Oral Experimental
result, Key study
NOAEL (Rat(Male), Inhalation): 1.1 mg/m3 Inhalation Experimental result,
Key study
Cyclohexene, 1-methyl-4-
(1-methylethenyl)-, (4R)-
NOAEL (Rat(Male), Oral, 13 Weeks): 600 mg/kg Oral Experimental result,
Key study
Silica
NOAEL (Rat(Female, Male), Oral, 13 Weeks): 4,000 mg/kg Oral
Experimental result, Key study
NOAEL (Rat(Female, Male), Inhalation): 1.3 mg/m3 Inhalation Experimental
result, Key study
Benzene, dimethyl-
NOAEL (Rat(Female), Oral, 90 d): 150 mg/kg Oral Experimental result, Key
study
White mineral oil
(petroleum)
NOAEL (Rat(Female, Male), Oral, 90 d): >= 20,000 ppm(m) Oral
Experimental result, Key study
NOAEL (Rabbit(Female, Male), Dermal): 1,000 mg/kg Dermal Read-across
from supporting substance (structural analogue or surrogate), Key study
LOAEL (Rat(Female, Male), Inhalation): 210 mg/m3 Inhalation Experimental
result, Key study
Aluminum oxide (Al2O3)
NOAEL (Rat, Inhalation, 6 - 12 Months): 70 mg/m3 Inhalation Experimental
result, Key study
LOAEL (Rat(Female, Male), Oral, 28 - 53 d): 1,000 mg/kg Oral Read-across
from supporting substance (structural analogue or surrogate), Weight of
Evidence study
Acetic acid, butyl ester
NOAEL (Rat(Female, Male), Inhalation, 13 Weeks): 500 ppm(m) Inhalation
Experimental result, Key study
Stoddard solvent
NOAEL (Rat, Inhalation - vapor): 1.9 mg/l (Target Organ(s): Nervous
System)
Benzene, ethyl-
NOAEL (Mouse(Female, Male), Inhalation, 104 Weeks): 75 ppm(m)
Inhalation Experimental result, Key study
NOAEL (Rat(Female, Male), Oral, 28 d): 75 mg/kg Oral Experimental result,
Key study