Supplementary Document

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SECTION 11. Toxicological information
Acute Toxicity
 Low level of acute toxicity predicted.
 May be harmful by skin absorption.
 Oral LD50 (rat) 5045mg/kg.
 Dermal LD50 (rabbit) 12800mg/kg.
 Inhalation LCLO (rat) 1600ppm 4h.
Chronic Toxicity / Carcinogenicity
 Material not expected to cause long-term adverse health effects.
 Material not classifiable as to its carcinogenicity to humans (Group 3).
 Chronic / Sub-chronic studies resulted in adverse effects to:
o Liver, spleen, biochemical effects, brain tissue degeneration,
changes in reflex behavior, sensory nerve damage.
Genealogy Toxicity
 Material is not expected to cause any mutagenic effects.
Reproductive / Developmental Toxicity
 Material is not expected to cause reproductive or developmental health effects.
 Experimental studies in animals have provided some evidence of embryo /
fetus toxicity and birth defects only at does producing marked maternal
toxicity.
SECTION 12. Ecological information
 Mobility
 If released to soil, IPA is expected to have very high mobility
 Persistence / Degradability