Technical data

Phoenix
Getting Started Guide
50
3
Pharmacokinetic modeling
1. In the File menu select Import or click the Import button. The Open
File(s) dialog is displayed.
2. Navigate to the Phoenix examples subdirectory, which by default is located at
C:\Program Files\Pharsight\Phoenix\applica-
tion\Examples.
3. Select the Legacy WinNonlin subdirectory.
4. In the Files of type menu select WinNonlin Files
(*.cmd;*.pco;*.pmo;*.pto;*.pwo).
5. Select Exp1.pmo and click Open.
The Data Import Wizard is displayed. The wizard is used to assign options for
how the data are imported and presented.
6. Click Finish. The data set is added to the project’s Data folder.
The Exp1.pmo file adds:
– A data set in workbook form (exp1).
– Data sets in workbook form for dosing and the stripping dose
(Exp1_sources).
– A PK Model object named Exp1.
7. Click the (+) symbols beside exp1 and Exp1_sources in the Data folder to
view the data sets’ worksheets.
8. Select the PK Model object Exp1 in the Object Browser. The PK Model
object’s Setup tab is displayed in the right viewing panel.
9. Select items in the PK Model object’s Setup tab list to explore the model’s
data mappings and option settings.
The imported PK Model object uses PK Model 13, which is a two compartment
model with 1st order absorption.
10.Click the Execute button. The Results are displayed on the Results tab.
Worksheet results
The PK Model object’s output worksheets partially include Condition Numbers,
Diagnostics, Dosing Used, Final Parameters, Initial Estimates, Secondary Param-