Technical data

Testing the Installation

Confirm model functions

This section tests examples of noncompartmental analysis, pharmacokinetic

modeling, bioequivalence, and population modeling.

Noncompartmental analysis

1. In the File menu select Import or click the Import button. The Open

File(s) dialog is displayed.

2. Navigate to the Phoenix examples subdirectory, which by default is located at

C:\Program Files\Pharsight\Phoenix\applica-

tion\Examples.

3. Select the Legacy WinNonlin subdirectory.

4. In the Files of type menu select WinNonlin Files

(*.cmd;*.pco;*.pmo;*.pto;*.pwo).

5. Select Profiles.pmo and click Open.

The Data Import Wizard is displayed. The wizard is used to assign options for

how the data are imported and presented.

6. Click Finish. The data set is added to the project’s Data folder.

A file in PMO (Pharsight Model Object) format is added to the Data folder as one

or more workbook objects. A .pmo file also adds one or more operational objects

to the project.

The Profiles.pmo file adds:

– A data set in workbook form (profiles).

– Data sets in workbook form for partial areas and dosing

(Profiles_sources).

– An NCA model object (model 200) named Profiles.

7. Click the (+) symbols beside profiles and Profiles_sources in the Data folder

to view the data sets’ worksheets.

8. Select the NCA model object Profiles in the Object Browser. The NCA

object’s Setup tab is displayed in the right viewing panel.

CAUTION: Models saved in PMO format contain all the necessary data mappings and

option settings. Do not change these settings.