White Papers

Dell - Internal Use - Confidential

Bright Cluster Manager

Bright Computing is a commercial software that provides comprehensive software solutions for deploying and managing HPC clusters,

big data clusters and OpenStack in the data center and in the cloud (6). Bright cluster Manager can be used to deploy complete

clusters over bare metal and manage them effectively. Once the cluster is up and running, the graphical user interface monitors every

single node and reports if it detects any software or hardware events.

BioBuilds

BioBuilds is a well maintained, versioned, and continuously growing collection of open-source bio-informatics tools from Lab7 (7). They

are prebuilt and optimized for a variety of platforms and environments. BioBuilds solves most software challenges faced by the life

sciences domain.

 Imagine a newer version of a tool being released. Updating it may not be straight forward and would probably involve updating

all of the dependencies the software has as well. BioBuilds includes the software and its supporting dependencies for ease of

deployment.

 Using BioBuilds among all of the collaborators can ensure reproducibility since everyone is running the same version of the

software. In short, it is a turnkey application package.

PERFORMANCE EVALUATION AND ANALYSIS

ALIGNER SCALABILITY

This is a base-line test to obtain information useful to set up fair performance tests. Burrows-Wheeler Aligner (BWA) short sequence

aligner is tested here since it is a key application in variant analysis pipelines for whole genome sequencing data. There are more than

90 short read alignment programs available as you can see in Figure 9 (8). Traditional sequence alignment tools like BLAST are not

suited for NGS. To extract meaningful information from NGS data, one needs to align millions and millions of mostly short sequences.

BLAST and similar tools are way to slow for the vast amount of data produced by modern sequencing machines.

Figure 9 Aligners currently available