Reference Guide

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21 Reference Architecture of Dell EMC Ready Solution for HPC Life Sciences | Document 309
4 Conclusion
Overall, 2nd Gen CPUs tested here perform slightly better over Skylake CPUs for genomics workloads such
as variant Calling and de novo Assembly. In addition to performance advantages, 2nd Gen CPUs provide
more choices compared to the predecessors in terms of lower TDP and higher core count for variant calling
kinds of workloads. It is notable that 1 DPC configuration with DDR4 2933 MHz DIMMS does not improve
performance for SOAPdenovo2. For de novo assembly applications, larger memory bandwidth seems to be
better; hence, there is no benefit from upgrading memory to DDR4 2933MHz in 1 DPC configuration for 2nd
Gen CPUs. It is recommended to set up a 2 DPC configuration with DDR4 2666 MHz, especially for de novo
assembly applications.