19085-1701857-UL_Prop_65_Test_Results_2019

CA Prop 65 Cumene NSRL February 11, 2019 Page 4 | 12
Species/Sex Tumor Type
Exposure Level (ppm)
Trend test
1
0
250
500
1,000
Lung
(alveolar/bronchiolar
carcinoma)
9/50 19/50* 32/50** 33/50** p < 0.001
Lung
(alveolar/bronchiolar
adenoma or
carcinoma)
19/50 38/50** 42/50** 43/50** p < 0.001
Spleen
(haemangiosarcoma)
0/50 0/50 0/49 4/50* NS
All organs
(haemangiosarcoma)
0/50 1/50 2/50 4/50 p = 0.002
Thyroid gland
(follicular-cell
adenoma)
0/50 0/50 0/49 3/50 p = 0.01
Female
Mouse
B6C3F
1
Exposure Level (ppm)
0
125
250
500
Lung
(alveolar/bronchiolar
adenoma)
1/50 26/50** 36/50** 38/50** p < 0.001
Lung
(alveolar/bronchiolar
carcinoma)
3/50 16/50** 20/50** 34/50** p < 0.001
Lung
(alveolar/bronchiolar
adenoma or
carcinoma)
4/50 31/50** 42/50** 46/50** p < 0.001
Liver (hepatocellular
adenoma)
18/50 23/50 27/50 29/50* p = 0.04
Liver (hepatocellular
carcinoma)
10/50 7/50 6/50 12/50 NS
Liver (hepatocellular
adenoma or
carcinoma)
25/50 26/50 29/50 36/50* p = 0.024
1
Exact test for linear trend
* p<0.01, pairwise comparison with controls by Fisher exact test.
** p<0.001, pairwise comparison with controls by Fisher exact test.