19085-1701857-UL_Prop_65_Test_Results_2019

CA Prop 65 Cumene NSRL February 11, 2019 Page 2 | 12
SUMMARY OF FINDINGS
This report describes the derivation of a cancer potency estimate and NSRL for cumene (CAS#
98-82-8). To estimate the human cancer potency the linearized multistage model was applied
to dose response data for increased incidence of lung tumors (alveolar/bronchiolar adenoma or
carcinoma) in B6C3F
1
mice exposed via inhalation. The potency derivation takes into account
differences in respiration rate and body size between humans and experimental animals.
The Proposition 65 NSRL is defined in regulation as the daily intake level posing a 10
-5
lifetime
risk of cancer. The human cancer potency estimate for cumene is 0.191 (mg/kg-day)
-1
and the
corresponding NSRL is 3.7 μg/day.
Table 1. Cancer Potency and NSRL for Cumene
Chemical
Cancer Slope Factor
(mg/kg-day)
-1
NSRL
(µg/day)
Cumene
0.191
3.7
NOTE: THIS REPORT IS PROVIDED FOR INFORMATION PURPOSES ONLY AND IS
NOT INTENDED TO CONVEY LEGAL ADVICE REGARDING COMPLIANCE WITH
CALIFORNIA’S SAFE DRINKING WATER AND TOXIC ENFORCEMENT ACT OF 1986
(PROPOSITION 65) OR OTHERWISE. IT IS DEFLECTO LLC SOLE RESPONSIBILITY
TO DETERMINE WHETHER A LABEL OR OTHER WARNING IS REQUIRED UNDER
PROPOSITION 65.