SDS

GardenTech Daconil Fungicide Ready to Use
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11. TOXICOLOGICAL INFORMATION
Acute effects of exposure:
Inhalation: Inhalation may cause irritation of the mucous membranes and upper respiratory tract.
Ingestion: No adverse effects are expected for small quantities ingested. Ingestion of large
quantities may cause gastrointestinal irritation with diarrhea and vomiting.
Skin contact: Prolonged skin contact may cause skin irritation. Prolonged or repeated contact may
cause allergic skin reaction (sensitization).
Eye contact: Contact may cause eye irritation.
Chronic Effects: In dogs, 1 year administration of Chlorothalonil caused a significant decrease in
body weight gain and increases in absolute liver and kidney weights.
Sensitization: Product may cause skin sensitization.
Germ Cell Mutagenicity: Neither chlorothalonil nor its metabolites interact with DNA and thus are
not mutagenic. Chlorothalonil was negative in the Ames assay and the micronucleus test in mice
bone marrow.
Reproductive Toxicity: None of the components are reproductive hazards. Chlorothalonil did not
cause teratogenic effects in rabbit or rats in oral studies.
Carcinogenicity: Chlorothalonil is classified by IARC as Possibly Carcinogenic to Humans (2B). No
evidence of carcinogenicity in dogs after administration for up to one year. Treatment related
increases in the incidence of renal tubular and carcinoma re observed in rats and male mice.
Squamous cell adenomas and carcinomas were also observed in the forestomach of both species.
The forestomach tumors seen in rodent studies re not relevant to human health, as humans do not
possess an anatomical equivalent of the rodent forestomach. The relevance of renal tumors to
human health is unclear, although metabolism data suggest that the dog, a species that is resistant to
chlorothalonil-induced renal injury, may be more representative of humans than the rat. Tumor
formation has been related to a non-genotoxic mechanism of action for which threshold levels have
been established in rats and mice. Comprehensive dietary and worker exposure studies have shown
exposure levels for humans to be well below these threshold levels. In addition, surveillance of
chlorothalonil plant workers for over twenty years has not demonstrated any increase in oncogenic
potential to humans. None of the other components are listed as carcinogens or suspected
carcinogens by IARC, NTP, ACGIH or OSHA.
Acute Toxicity Values: Calculated ATE (inhalation): 114.9 mg/l (mist)
Chlorothalonil: Oral rat LD50: >10,000 mg/kg; Inhalation rat LC50: 0.1 mg/L/4hr; Dermal rat LD50:
>2500 mg/kg
12. ECOLOGICAL INFORMATION
Ecotoxicity values: This product is toxic to aquatic invertebrates and wildlife. To protect the
environment, do not allow pesticide to enter or run off into storm drains, drainage ditches, gutters or
surface waters. Applying this product in calm weather when rain is not predicted for the next 24
hours will help to ensure that wind or rain does not blow or wash pesticide off the treatment area.
This chemical is known to leach through soil into groundwater under certain conditions as a result of
label use. Use of this chemical in areas where soils are permeable, particularly where the water table
is shallow, may result in groundwater contamination.
Chlorothalonil: Bees LC/EC50: >181 ug/bee; Daphnia magna LC50/EC50: 0.068 ppm; Trout
LC/EC50: 0.04 ppm; Bluegill LC/EC50: 0.06 ppm; Birds – Bobwhite Quail LC50/EC50: >5200 ppm/8-
days; Birds – Mallard Duck LC50/EC50: >5,200 ppm/8-hr
Persistence and degradability: Chlorothalonil is not persistent in soil or water.
Bioaccumulative potential: Chlorothalonil has a low to moderate bioaccumulation potential.
Mobility in soil: Chlorothalonil has low mobility in soil.