User guide

What’s new
ChemBioDraw has long been the preferred tool for illustrating chemical and biological concepts. ChemBioDraw 13.0
introduces a variety of improvements and new features that are briefly described below. You can find more information
on these and other features throughout the PDF guide and online help. Please note that the contents of both these doc-
uments are identical; they only differ in format.
Biopolymer Builder Enhancements. Methods for building and displaying biopolymers are greatly enhanced in
ChemBioDraw 13.0:
Single and multi letter amino acids - You can create single letter amino acids and nucleotides either by entering the
corresponding IUPAC code or using the Biopolymer toolbar. The Biopolymer Editor lets you create three letter or
non-standard amino acids by entering the residue name.
The ‘Toggle Amino Acid Style AA1<->AA3’ command lets you change the amino acid representation from sin-
gle to multi-letter, and vice versa. For more information, see "Drawing biopolymers" on page 60.
L- and D- amino acids - You can create standard L- or D-amino acids by entering the relevant IUPAC code.
Toggle L- and D-amino acids -The ‘Toggle Amino Acid Stereo L<->D’ command lets you change the ster-
eochemistry of amino acids from L to D and vice versa .
Protecting groups - You can add protecting groups such as Trt and Fmoc to amino acids containing additional NH
2
or OH groups (Arg, Aad). You can also expand and contract the protected residues. For more information, see "Pro-
tecting groups" on page 62.
Cyclic and branched peptides - ChemBioDraw 13.0 lets you create cyclic peptides by bonding together the terminal
residues in a peptide sequence. A looped bond indicates that the peptide is cyclic. You can create branched pep-
tides using the sequence builder and bond tools. For more information, see "Cyclic, crosslinked, and branched pep-
tides" on page 72.
ChemBioDraw 13.0
What’s new vi