User guide

You use the generic reaction to search your chemical database for compounds that match the reactant query struc-
tures. Once all the matching compounds are found, CombiChem generates a list of reactions from the compounds
that were found in the query.
The generic reaction you create must meet these criteria:
All generic atoms in the reactant(s) must be represented by R-groups.
Solvents, catalysts, and other “real-world” elements must not be included in the generic reaction.
Multi-step generic reactions are supported.
Entering a generic reaction
To enter the generic reaction, you must first create a reaction worksheet:
Go to ChemOffice13>CombiChem>New Reaction. A new worksheet, named “Reactions” appears in your work-
book.
You then add the generic reaction to the reaction worksheet by either importing it or drawing it in ChemBioDraw.
To import the reaction:
1. Place your cursor in the cell that contains the text “Reaction - Double-click to edit.”
2. Either click the Load Molecule icon on the ChemOffice toolbar or go to ChemOffice13>Molecule>Load.
3. Browse to the file that contains the generic reaction and click Open. The reaction appears in the Reactions work-
sheet.
To draw the reaction in ChemBioDraw:
1. Double-click the cell that contains the text “Reaction - Double-click to edit.”.
2. When asked whether to add a new molecule, click Yes. ChemBioDraw launches.
ChemBioDraw 13.0
Chapter 10: ChemDraw/Excel 189 of 401