SDS

Bayer Environmental Science
Material Safety Data Sheet
MSDS Number: 102000012168
BAYER ADVANCED DISEASE CONTROL FOR ROSES,
FLOWERS & SHRUBS CONCENTRATE
MSDS Version 2.0
Page 5 of 7
OSHA
None.
Reproductive &
Developmental Toxicity
REPRODUCTION: In a two generation study in rats treated with tebuconazole,
smaller litters and decreased pup body weights were observed in conjunction
with maternal toxicity at the highest concentration tested (1000 ppm).
DEVELOPMENTAL TOXICITY: Tebuconazole produced teratogenic effects in
conjunction with maternal toxicity in mice and rabbits via oral and/or dermal
exposure. When tested in the rat, developmental effects were observed in
conjunction with maternal toxicity via oral exposure. Teratogenic effects were
not observed in the rat following either route of exposure.
Neurotoxicity
In an acute oral neurotoxicity screening study in rats, tebuconazole produced
transient neurobehavioral effects without correlating morphological changes in
neural tissues.
In a subchronic dietary neurotoxicity screening study in rats, tebuconazole did
not produce any neurobehavioral symptoms or any microscopic lesions in neural
tissues or skeletal muscle.
In a one-generation developmental neurotoxicity study in rats, dietary
concentrations of tebuconazole administered to the dams during gestation and
lactation did not cause any specific neurobehavioral effects in the offspring.
Clinical signs of toxicity, as well as, developmental toxicity were observed in the
offspring, but only in conjunction with maternal toxicity.
Mutagenicity
Numerous in vitro and in vivo mutagenicity studies have been conducted on
tebuconazole all of which were negative.
SECTION 12. ECOLOGICAL INFORMATION
Environmental
Precautions
This product is toxic to aquatic invertebrates. Do not apply directly to water. Drift
or runoff may harm aquatic invertebrates. Do not contaminate surface or ground
water by cleaning equipment or disposal of wastes, including equipment wash
water.