SDS

Bayer Environmental Science
Material Safety Data Sheet
MSDS Number: 102000012168
BAYER ADVANCED DISEASE CONTROL FOR ROSES,
FLOWERS & SHRUBS CONCENTRATE
MSDS Version 2.0
Page 4 of 7
Chemical Stability
Stable under normal conditions.
SECTION 11. TOXICOLOGICAL INFORMATION
Acute toxicity studies have not been performed on this product as formulated. The acute toxicology
information provided below is from a similar formulation containing a higher percentage of the active
ingredient, tebuconazole. The non-acute information pertains to the active ingredient, tebuconazole.
Acute Oral Toxicity
male/female rat: LD50: > 2,000 mg/kg
Acute Dermal Toxicity
male/female rat: LD50: > 4,000 mg/kg
Acute Inhalation Toxicity
male/female rat: LC50: > 1.975 mg/l
Exposure time: 4 h
Determined in the form of liquid aerosol.
male/female rat: LC50: > 7.9 mg/l
Exposure time: 1 h
Determined in the form of liquid aerosol.
Extrapolated from the 4 hr LC50.
Skin Irritation
rabbit: slight irritation
Eye Irritation
rabbit: non-irritant
Sensitization
guinea pig: Non-sensitizing
Subchronic Toxicity
In a 3 week dermal toxicity study, rabbits treated with tebuconazole showed no
local or systemic effects at levels up to and including 1000 mg/kg, the limit dose.
In a 3 week inhalation study, rats exposed to tebuconazole exhibited liver
enzyme effects at the highest concentration tested (155.8 mg/m³).
Chronic Toxicity
In chronic dietary studies in rats and dogs treated with tebuconazole, effects on
the liver, spleen, adrenals and/or eyes occurred at high doses.
Assessment Carcinogenicity
Tebuconazole gave no evidence of a carcinogenic potential in an oncogenicity study in rats, however, in a
study using mice there was an increased incidence of hepatocellular neoplasms at a dose level
approximately three-fold greater than the maximum tolerated dose (MTD).
ACGIH
None.
NTP
None.
IARC
None.