SDS

11. TOXICOLOGICAL INFORMATION (Continued)
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concentrations of 0.46, 2.55 or 11.9 mg/m3 for 6 hours/day. NOELs for
maternal and developmental toxicity were less than 0.46 and 0.46 mg/m3,
respectively.
REPRODUCTION..........: In a reproduction study, cyfluthrin was administered to
rats for 3 generations at dietary concentrations of 50, 150 and 450 ppm.
Reproductive effects observed at parentally toxic levels included reductions
in viability, lactation, litter size, feed consumption, and pup birth weights
and body weight gains. Coarse tremors were observed in some offspring at 450
ppm. The NOEL for both parental and reproductive effects was 50 ppm. In
another reproduction study, cyfluthrin was administered to rats for 2
generations at dietary concentrations of 50, 125 or 400 ppm. Coarse tremors
occurring in conjunction with parental toxicity were observed in the offspring
in the mid- and high-dose groups. Based on this finding, the neonatal NOEL
was 50 ppm. The NOELs for parental and reproductive toxicity were 50 and 400
ppm, respectively.
NEUROTOXICITY ........: Numerous neurotoxicity studies have been conducted on
cyfluthrin. Oral gavage studies using hens have indicated that at extremely
high dose levels (5000 mg/kg), minimal nerve damage occurs. When rats were
administered cyfluthrin daily at oral doses of 40 to 80 mg/kg for 14 days,
minimal nerve effects were seen. These effects were completely reversible
within a 3 month recovery period. In dermal and inhalation studies which are
more relevant to field exposure, there was no evidence of delayed
neurotoxicity in hens. In a special investigative study, litters of neonatal
mice (10 days of age) and their mothers were exposed to cyfluthrin via
inhalation (whole body exposure). Mice were exposed to aerosol concentrations
of 5, 15, or 50 mg/m3 for 6.3 hours/day for 7 successive days. Motor activity
was measured in the offspring at 4 months of age (approximately 3.5 months
post-exposure). At 50 mg/m3, all of the offsprings died or were sacrificed in
a moribund state following the first exposure. Mortalities were not observed
at any of the other levels. Clinical symptoms were observed immediatley after
exposure in young mice at 15 mg/m3, and included decreased motility, temporary
scratching, and tonic convulsions. There was an increase in motor activity in
mice at 15 mg/m3. Histopathological investigations did not reveal any
treatment-related findings in mice at the age of 4 months.
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12. ECOLOGICAL INFORMATION:
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This product is highly toxic to fish. Bayer will provide a summary of specific
data upon written request. As with any pesticide, this product should be used
according to label directions and should be kept out of streams, lakes and
other aquatic habitats of concern.
Product Code: 41741 MSDS Page 7
Approval date: 11/07/2001 Continued on next page