User manual

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are roughly 5% to 10% too high. Since Rm = Vpulse / Isteadystate - Rs is the theoretically correct
function, it is now used in the Rm calculation when Rs is being measured. Note, however, that since Rs
is usually slightly overestimated, Rm now will be slightly too low!!!
In WinLTP, Rs is almost always measured during patch clamp voltage clamping (assuming you click the
AnalysesToDo Rs check box), but is not measured during patch clamp current clamping, and therefore Rs
= 0 in this case, and Rm = V
Pulse
/ I
SteadyState
. Furthermore, during whole cell single electrode voltage
clamping, where series resistance is theoretically zero, you would not measure Rs and it would therefore
be set to Rs = 0, and Rm = V
Pulse
/ I
SteadyState
. For intracellular current clamping using a bridge circuit, Rs
would also not be measured and would therefore be set to Rs = 0, and Rm = V
Pulse
/ I
SteadyState
.