User manual

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4.11.11 Patch Electrode Series Resistance (Rs)
The patch electrode series resistance (Rs) can either be calculated from the 1) peak of the capacitative
transient, 2) the extrapolated peak of the capacitative transient fitted by a single exponential, or 3) the
extrapolated peak of the capacitative transient fitted by a double exponential. I would like to thank Dr.
Tim Benke for the single and double exponential fitting code, and for many discussions about measuring
Rs.
For a discussion on the correct measurement of series resistance with and without using exponential
curve fitting, and cell input resistance measurement see Ogden and Stanfield (Patch clamp techniques for
single channel and whole-cell recording, In: Microelectrode Techniques, The Plymouth Workshop
Handbook, Second Edition, Ed. D. Ogden, The Company of Biologists Ltd., Cambridge, 1994).
Fig. 4.11.11.1. Series and Input Resistance Calculation Methods Dialog Box. Series Resistance and
Input Resistance, Rm can now be made from Channel AD0 and/or AD1.