User guide

DuoSpray™ Ion Source User Reference
System User Guide
D5033331 A
AB SCIEX TripleTOF
®
5600/5600+ Instruments
95 of 116
Optimize the APCI Probe Temperature
The quantity and type of solvent affects the optimal APCI probe temperature. At higher flow
rates, the optimal temperature increases.
• Adjust the TEM parameter in increments of 50°C to achieve the best signal or signal-
to-noise ratio.
Optimize for the Compound
• Adjust the DP value in increments of 10 to achieve the best signal or signal-to-noise
ratio. DP optimizes between 60 to 200.
Maintenance
To determine how often to clean the ion source or perform preventive maintenance, consider the
following:
• Compounds tested
• Cleanliness of the preparation methods
• Amount of time an idle probe contains a sample
• Overall system run time
These factors can cause changes in mass spectrometer performance, indicating that
maintenance is required.
Perform periodic gas leakage tests and general maintenance inspections to be sure of safe
operation of the system. Clean the ion source regularly to keep it in good working condition.
Caution: Potential Instrument Damage: Use only the recommended cleaning method to
avoid damaging the equipment.
Clean the Probes
Flush the ion source periodically, regardless of the type of compounds sampled. Do this by
setting up a method in the Analyst TF software specifically for performing a flushing operation.
WARNING! Toxic Chemical Hazard: Vent the source exhaust system to an
external fume hood or an external vent to prevent hazardous vapors from being
released into the laboratory environment.
Required tools
• 1/4 inch open-ended wrench
• 9/64 inch Allen key (supplied)
• 5 mm Allen key
• 2.5 mm Allen key
• Phillips screwdriver
• Slotted screwdriver