User guide

DuoSpray™ Ion Source User Reference
System User Guide
D5033331 A
AB SCIEX TripleTOF
®
5600/5600+ Instruments
85 of 116
APCI Probe
The APCI probe is suitable for:
• Ionization of compounds that do not readily form ions in solution. These are usually
non-polar compounds.
• Creation of simple APCI spectra for MS/MS experiments.
• High-throughput analyses of complex and dirty samples. It is less sensitive to ion
suppression effects.
• Rapid sample introduction by flow injection with or without an LC column
The APCI probe can accept the entire effluent, without splitting, at flow rates from 50 µL/min to
3000 µL/min (through a wide bore column). It can vaporize volatile and labile compounds with
minimal thermal decomposition. The rapid desolvation and vaporization of the droplets and
entrained analyte minimizes thermal decomposition and preserves molecular identity for
ionization by the corona discharge needle. Buffers are readily tolerated by the ion source without
significant contamination and the flash vaporization of the sprayed effluent allows up to 100%
water to be used without difficulty.
Figure 7-2 Parts of the TurboIonSpray probe
Item Description
1 Electrode adjustment nut (black collar) that adjusts the extension of the electrode tip
2 Bronze retaining ring that fastens the probe to the probe tower on the ion source
housing
3 Electrode tip through which samples are sprayed into the sample inlet area of the ion
source
3
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