Datasheet
Data Sheet  ADA4522-1/ADA4522-2/ADA4522-4
Rev. F | Page 27 of 33 
APPLICATIONS INFORMATION 
SINGLE-SUPPLY INSTRUMENTATION AMPLIFIER 
The extremely low offset voltage and drift, high open-loop gain, 
high common-mode rejection, and high power supply rejection of 
the ADA4522-1/ADA4522-2/ADA4522-4 make them excellent op 
amp choices as discrete, single-supply instrumentation amplifiers. 
Figure 82 shows the classic 3-op-amp instrumentation amplifier 
using the ADA4522-1/ADA4522-2/ADA4522-4. The key to high 
CMRR for the instrumentation amplifier are resistors that are well 
matched for both the resistive ratio and relative drift. For true 
difference amplification, matching of the resistor ratio is very 
important, where R5/R2 = R6/R4. The resistors are important 
in determining the performance over manufacturing tolerances, 
time, and temperature. Assuming a perfect unity-gain difference 
amplifier with infinite common-mode rejection, a 1% tolerance 
resistor matching results in only 34 dB of common-mode rejection. 
Therefore, at least 0.01% or better resistors are recommended. 
V
IN1
V
IN2
A1
A3
A2
R
G1
R
G2
R1
R3
R2
R4
R5
V
OUT
R6
R
G1
 =R
G2
, R1 = R3, R2 = R4, R5 = R6
V
OUT
 =(V
IN2
 –V
IN1
)(1 + R1/R
G1
)(R5/R2)
13168-078
Figure 82. Discrete 3-Op-Amp Instrumentation Amplifier 
To build a discrete instrumentation amplifier with external resis-
tors without compromising on noise, pay close attention to the 
resistor values chosen. R
G1
 and R
G2
 each have thermal noise that 
is amplified by the total noise gain of the instrumentation amplifier 
and, therefore, a sufficiently low value must be chosen to reduce 
thermal noise contribution at the output while still providing an 
accurate measurement. Table 10 shows the external resistors noise 
contribution referred to the output (RTO). 
Table 10. Thermal Noise Contribution Example 
Resistor 
Value 
(kΩ) 
Resistor Thermal 
Noise (nV/√Hz) 
Thermal Noise 
RTO (nV/√Hz) 
R
G1
 0.4 2.57  128.30 
R
G2
 0.4 2.57  128.30 
R1 10  12.83  25.66 
R2 10  12.83  25.66 
R3 10  12.83  25.66 
R4 10  12.83  25.66 
R5 20  18.14  18.14 
R6 20  18.14  18.14 
Note that A1 and A2 have a high gain of 1 + R1/R
G1
. Therefore, 
use a high precision, low offset voltage and low noise amplifier 
for A1 and A2, such as the ADA4522-1/ADA4522-2/ADA4522-4. 
Conversely, A3 operates at a much lower gain and has a differ-
ent set of op amp requirements. Its input noise, referred to the 
overall instrumentation amplifier input, is divided by the first 
stage gain and is not as important. Note that the input offset 
voltage and the input voltage noise of the amplifiers are also 
amplified by the overall noise gain. 
Any unused channel of the ADA4522-1/ADA4522-2/ADA4522-4 
must be configured in unity gain with the input common-mode 
voltage tied to the midpoint of the power supplies. 
Understanding how noise impacts a discrete instrumentation 
amplifier or a difference amplifier (the second stage of a 3-op-
amp instrumentation amplifier) is important, because they are 
commonly used in many different applications. The Load 
Cell/Strain Gage Sensor Signal Conditioning section and the 
Precision Low-Side Current Shunt Sensor section show the 
ADA4522-1/ADA4522-2/ADA4522-4 used as a discrete 
instrumentation or difference amplifier in an application. 
LOAD CELL/STRAIN GAGE SENSOR SIGNAL 
CONDITIONING USING THE ADA4522-2 
The ADA4522-2, with its ultralow offset, drift, and noise, is well 
suited to signal condition a low level sensor output with high gain 
and accuracy. A weigh scale/load cell is an example of an 
application with such requirements. Figure 83 shows a configura-
tion for a single-supply, precision, weigh scale measurement 
system. The ADA4522-2 is used at the front end for amplification 
of the low level signal from the load cell. 
Current flowing through a PCB trace produces an IR voltage 
drop; with longer traces, this voltage drop can be several 
millivolts or more, introducing a considerable error. A 1 inch 
long, 0.005 inch wide trace of 1 oz copper has a resistance of 
approximately 100 mΩ at room temperature. With a load 
current of 10 mA, the resistance can introduce a 1 mV error. 
Therefore, a 6-wire load cell is used in the circuit. The load cell 
has two sense pins, in addition to excitation, ground, and two 
output connections. The sense pins are connected to the high 
side (excitation pin) and low side (ground pin) of the 
Wheatstone bridge. The voltage across the bridge can then be 
accurately measured regardless of voltage drop due to wire 
resistance. The two sense pins are also connected to the analog-
to-digital converter (ADC) reference inputs for a ratiometric 
configuration that is immune to low frequency changes in the 
power supply excitation voltage. 
The ADA4522-2 is configured as the first stage of a 3-op-amp 
instrumentation amplifier to amplify the low level amplitude 
signal from the load cell by a factor of 1 + 2R1/R
G
. Capacitors 
C1 and C2 are placed in the feedback loops of the amplifiers 
and interact with R1 and R2 to perform low-pass filtering. This 
filtering limits the amount of noise entering the Σ- ADC. In 
addition, C3, C4, C5, R3, and R4 provide further common-mode 
and differential mode filtering to reduce noise and unwanted 
signals. 
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