User guide

62 Multimode Source for 6100 Series Single Quad LC/MS User Guide
3 Reference
Guidelines for positive/negative polarity switching in mixed mode
NOTE
The above set of parameters is provided as a starting point and should yield good response
for many analytes. To obtain a specific response, i.e., high sensitivity detection of a
compound or class of compounds, or a balanced response to a wide variety of compound
classes, these parameters and the LC mobile phase composition should be examined
further using traditional techniques for optimizing a method.