User guide

58 Multimode Source for 6100 Series Single Quad LC/MS User Guide
3 Reference
Guidelines
Guidelines
Guidelines for multimode source settings in MM-ES mode
Nebulizer pressure Always set to 60 psi.
Drying gas flow Always set to 5 L/min (IR does the drying).
Drying gas temperature Depends on the vaporizer temperature. A good
starting temperature is 250°C. If running a cold vaporizer temperature, then
set the drying gas temperature to vapor temperature or lower. If running the
vaporizer hot (>175°C), then set the drying gas temperature to 350°C.
Remember you want the vaporizer to control the drying and to be able to
maintain the set point.
Vaporizer Start at 150°C. ESI works across a broad vaporizer range. If you are
getting excessive sodium adducts, lower the temperature. You can run as low
as 60°C. It is recommend to run 100°C or greater. Negative ion TFA adducts
work best at lower temperature (<150°C).
Vcap Set to 2000 V. A lower voltage works better for fast switching. High
mass ions (>1000) prefer a higher Vcap.
Charging Voltage Set to 200 V.
NOTE
Click Instrument > MSD Spray Chamber to set the Method Spray Chamber to
MM-ES+APCI before you edit the Set Up MSD Signals dialog box.