User guide

Contents
Multimode Source for 6100 Series Single Quad LC/MS User Guide 5
Content
1 Basic Operation and Maintenance 7
Setting up Methods 8
To setup a method to use the multimode source 8
To create a method for positive/negative mixed mode operation 9
To create a method for alternating ESI and APCI operation 11
Maintenance 13
To open the multimode source 13
To turn off the instrument 15
To clean the multimode source daily 16
To clean the multimode source weekly 19
To bake out the LC/MS 21
To do an autotune 22
2 Installation 23
Step 1. Prepare to install 24
Step 2. Install the HV control PCA and cables 25
To remove the multimode source 29
To convert from multimode to ESI, APCI or APPI 30
To convert from ESI, APCI or APPI to the multimode source 31
3 Reference 37
Safety and Specifications 38
Safety 38
Safety Symbols 42
Technical Specifications 43
Overview 44
Benefits of a multimode source 44
Mobile phase considerations when using the multimode source 52
Flowchart summarizing parameter choices for different modes 54
Source comparison in positive ion mode 55