User guide

16 Multimode Source for 6100 Series Single Quad LC/MS User Guide

1 Basic Operation and Maintenance

To clean the multimode source daily

You should clean the multimode source daily or any time you suspect

carryover (contamination) from one sample or analysis to another. The

multimode source spray chamber is made of 316 stainless steal which is the

same material the spray shield is made of.

Before you begin, check that you have:

• Abrasive paper, 8000 grit (p/n 8660-0852)

• Cloths, clean, lint-free (p/n 05980-60051)

• Cotton swabs (p/n 5080-5400)

• Gloves

• Mobile phase from the current method or clean isopropanol, reagent

grade or better

• Wash bottle

• Water, reagent-grade or better

1 Turn off the spray chamber. Use the Spray Chamber menu item in Tune

and set all gas flows and temperatures to minimum values of zero.

2 Remover the nebulizer and APCI corona needle.

3 Remove the cosmetic cover. The thermocouple probe will need to be

removed if any wiping of the spray chamber will be done. Then, open the

spray chamber.

4 Rinse the interior of the spray chamber using the wash bottle filled with the

current mobile phase or with a mixture of isopropanol and water.

WARNING

Do not touch the multimode source or the capillary cap. They may be very hot. Let the

parts cool before you handle them.

NOTE

Recent residue should be soluble in the mobile phase. If you are not sure what mobile

phase was used recently, a mixture of 50% isopropanol and 50% water works well as a

general cleaning solution.