Technical data

28 Agilent 6200 Series TOF and 6500 Series Q-TOF LC/MS System Concepts Guide
1Overview
How does the Agilent TOF and Q-TOF mass spectrometer work?
How does the Agilent TOF and Q-TOF mass spectrometer work?
6200 Series TOF The Agilent TOF is an orthogonal acceleration time-of-flight
mass spectrometer (oa-TOF). The acceleration pulse applied to
send the ions down the flight tube is orthogonal to the direction
that ions are entering the mass analyzer. This geometry
minimizes the effect of the entrance velocity on the flight time,
leading to higher resolution.
6500 Series
Q-TOF
The Agilent 6500 Series Q-TOF LC/MS is a liquid
chromatograph Q-TOF mass spectrometer that performs MS/MS
using a quadrupole, a hexapole (collision cell) and
a time-of-flight unit to produce spectra. The quadrupole selects
precursor ions that are fragmented in the collision cell into
product ions, which are then impelled to the detector, at an
angle perpendicular to the original path.
The Agilent 6500 Series Q-TOF LC/MS supports several
atmospheric pressure ionization (API) sources. A common
atmospheric sampling interface introduces ions from these
various sources into the mass spectrometer vacuum system.
Figure 8 Schematic of Agilent 6520 Q-TOF LC/MS
Figure 8 shows the complete Agilent 6520
Q-TOF LC/MS schematic, including AJS
ESI ion source, ion transfer optics, beam
shaping optics, ion pulser, flight tube, and
detector.