Technical data

10 Agilent 6200 Series TOF and 6500 Series Q-TOF LC/MS System Concepts Guide
1Overview
How does the TOF and Q-TOF system help you do your job?
How does the TOF and Q-TOF system help you do your job?
You can set up an Agilent 6200 Series Time-of-Flight LC/MS
(TOF) system and the Agilent 6500 Series Quadrupole
Time-of-Flight LC/MS (Q-TOF) system in several configurations:
ESI – Electrospray Ionization
APCI – Atmospheric Pressure
Chemical Ionization
APPI - Atmospheric Pressure
Photo Ionization
HPLC-Chip/MS – High Performance
Liquid Chromatography on a Chip
MALDI – Matrix-Assisted Laser
Desorption Ionization
MMI - Multimode Ionization
• For normal flow LC/MS with a binary pump, quaternary
pump, well-plate sampler (or autosampler or HTC/HTS
autosampler) and ESI or Dual ESI with Agilent Jet Stream
Thermal Gradient Technology - Agilent 6530 Quadrupole
Time-of-Flight, Agilent 6540 Quadrupole Time-of-Flight,
Agilent 6550 iFunnel Quadrupole Time-of-Flight, and Agilent
6230 Time-of-Flight.
• For normal flow LC/MS with a binary pump, quaternary
pump, well-plate sampler (or autosampler or HTC/HTS
autosampler) and ESI, Dual ESI, APCI, APPI, or MMI ion
sources.
• For microflow LC/MS with a capillary pump, micro well-plate
sampler and ESI, Dual ESI, APCI or MMI ion sources
• For nanoflow LC/MS with a nanopump, micro well-plate
sampler and HPLC-Chip/MS interface (used in place of
standard or dual nanospray source) to increase reliability
and boost performance with narrow peak dispersion and
lower dead volumes.
• Agilent 6200 Series TOF or 6500 Series Q-TOF LC/MS system
with an AP-MALDI or PDF-MALDI source
Each Agilent system has advantages for high throughput sample
screening with highly sensitive detection and accurate mass
assignment. Each uses the same
Agilent 6200 Series TOF or 6500
Series Q-TOF LC/MS
software to enable these advantages.
The Agilent Accurate-Mass 6530 Q-TOF, the Agilent UHD
Accurate-Mass 6540 Q-TOF LC/MS, and the Agilent 6550
iFunnel Q-TOF LC/MS systems are the only Q-TOF instruments
that can use the Agilent Jet Stream Technology. The Agilent
6230 TOF LC/MS system is the only TOF that can use the
Agilent Jet Stream Technology. This technology utilizes a