Certifications 2

Reference No:
Valve Regulated Lead-acid Battery
Hitachi Chemical Energy Technology Co.,Ltd.
Page 13 / 20
Date of issuing: January 01, 2020
system. There is the description that the hemoglobin
synthesis inhibition and small blood cell anemia and
hypochromic anemia due to shortened of red blood cell life
are caused by δ-aminolevulinic acid and heme synthesis
enzyme are inhibited. Therefore, it is classified as
"Category 1 of GHS specific target organ toxicity (single
exposure) (blood system)".
Other, colic is the initial symptoms of occupational exposure
or high concentration acute exposure. Since there is the
description of the associated symptoms such as
constipation, severe abdominal pain, nausea, vomiting, loss
of appetite, it is classified as "Category 1 of GHS specific
target organ toxicity (single exposure) (digestive system)".
Specific target organ toxicity
(repeated exposure) :
Although there is no data of the substance, there is the
description that in high concentration repeated exposure by
lead and inorganic lead compounds, it leads to irreversible
changes to kidney including tubular atrophy, interstitial
fibrosis glomerular sclerosis, and eventually it cause
chronic nephritis. Therefore, it was classified as "Category 1
of GHS specific target organ toxicity (repeated exposure)
(kidney)".
In addition, there is the report of the lead epidemiological
study, hemoglobin concentration and hematocrit value of
poisoning patients were significantly decreased compared
with control subjects of non-exposure.
There is the description that the hemoglobin synthesis
inhibition and small blood cell anemia and hypochromic
anemia due to shortened of red blood cell life are caused by
δ-aminolevulinic acid and heme synthesis enzyme are
inhibited. Therefore, it was classified as "Category 1 of GHS
specific target organ toxicity (repeated exposure) (blood
system)".
On the other hand, there is the research study to support
the relationship between the chronic lead poisoning and
myocardial injury, and there is reported that abnormal
electrocardiogram in workers of lead poisoning was
observed. In addition, from the data of epidemiological
studies, since it has been concluded that internal absorption
of lead causes a significant increase in blood pressure in
both diastolic and systolic of the heart, it was classified as
Category 1 of GHS specific target organ toxicity (repeated
exposure) (cardiovascular).
Moreover, suppression of motor nerve conduction velocity
was observed in worker who blood concentration of lead is
high, and also there is a report of the Parkinson's syndrome